Regular provider assessment of collagen markers, elasticity changes, and systemic tolerance guides dose modifications
Sources of depletion can include: Mitochondrial energy production (a normal and essential process, but creates harmful byproducts like ROS) Chronic infections, gut dysbiosis (including SIBO and Candida ), and ongoing inflammation Air pollution, heavy metals, and environmental toxins 17 Ultra-processed foods, sugar-sweetened beverages, and foods high in advanced glycation end products (heavily browned foods) 18 Pesticides and herbicides 19 Alcohol and smoking Psychological stress Even vigorous exercise (a healthy stressor that still creates oxidative byproducts) 20 Understanding this helps explain why simply eating well sometimes isnt enough, and why targeted nutritional strategies make a meaningful difference
J Gen Intern Med 27:15871593 Wood SL, Westbrook JA, Brown JE (2014) Omic-profiling in breast cancer metastasis to bone: implications for mechanisms, biomarkers and treatment
This may indicate that additional layers of regulation exist as compared with cyanobacteria, microalgae or non-vascular plants as often observed for other metabolic pathways
10.1038/nn1486 71 LamsaK.HeeromaJ
